Oral Fluid Dose Correlation Testing
Individualized Drug Testing for Pain Management

Introducing Cordant CORE™

Register for a Professional Webinar Briefing on Cordant CORE™

Join us March 21 for a 20 minute Professional Briefing as Richard Stripp, Ph.D., Chief Scientific Officer at Cordant Health Solutions, explains how CORE gives clinicians the insight of steady-state blood testing while also offering the ease and benefits of oral fluid testing to help clinicians assess medication levels for their chronic pain patients.



CORE utilizes patient-specific information, including weight, dose, frequency and oral fluid pH, in evaluating whether or not the patient is within the expected steady-state range. The expected steady-state range is a pharmacokinetic calculation based upon the patient’s specific information. CORE does not attempt to apply averages for an entire population to a single patient test result. Rather, CORE is truly individualized medicine.


Sample collection is easy and noninvasive. CORE requires no specialized staff or facilities.


At most, traditional drug testing provides only a general idea of drug levels in the patient’s system, and sometimes can only provide yes/no answers. In contrast, CORE dives deeper, evaluating both if the drug is in the patient’s system AND if it is within the expected steady-state range for that patient’s prescribed dose and frequency.


CORE is a tool to help clinicians document adherence to a dosing regimen while adding another level of protection to the provider’s practice. CORE can give information to providers to use in identifying patients who may be taking their medication only prior to coming into the office and who would otherwise have a positive consistent drug test result, thus reducing fraud, waste and abuse.


CORE tells you whether a drug is present in the patient’s system and whether it is within the expected steady-state range for that patient with that dose and frequency. This gives providers new insight into a patient’s health to:

  • Help document that a patient has likely reached the expected steady-state range before increasing dosage
  • Review the treatment plan with the patient and determine what steps may be needed to provide optimum patient care


Because oral fluid is a filtrate of blood, it is affected by significantly fewer variables than urine; and because it is an observed collection, it has a very low risk of sample adulteration.


Providing the best care at the lowest cost is paramount in today’s health care system. CORE is billed as a normal definitive test, so there is no additional cost to receive CORE results. CORE can also be helpful in determining compliance and thus lowering a patient’s risk level. CORE results can also help evaluate if there is a potential for genetic abnormalities that may be interfering with a patient’s metabolism of a drug. If a patient falls above or below range, a genetic test may be indicated in some circumstances; CORE can help you better target whether or not there is a need for genetic evaluation.*

“As a research partner of Cordant and specifically CORE testing, I have had the opportunity to evaluate test results within my patient population. I have found the added information to be powerful in understanding how and when a patient is taking their medications, many times leading a more informed conversation with a patient. CORE gives a better indication of dose compliance – and this is especially important in light of new CDC guidelines.”

– Naum Shaparin, M.D.

Director of Pain Services

Montefiore Medical Center


  • Oxycodone
  • Hydrocodone
  • Morphine
  • Oxymorphone
  • Hydromorphone
  • Tramadol
  • Fentanyl

*Patients falling within range may still have genetic abnormalities.  Test results should not be substituted for professional clinical judgment.

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