Oral Fluid Dose Correlation Testing
Individualized Drug Testing for Pain Management

Introducing Cordant CORE™



CORE utilizes patient-specific information, including weight, dose, frequency and oral fluid pH, in its patent-pending algorithm, providing insight to providers to help evaluate whether a patient is within the expected steady state range via oral fluid testing. The expected steady state range is a pharmacokinetic calculation based upon the patient’s specific dosing information, which prior to CORE, required blood sampling for evaluation. CORE does not attempt to apply population averages to a single patient test result. Rather, CORE is a truly individualized clinical tool.


Sample collection is easily observed and noninvasive. CORE requires no specialized staff or facilities.


Traditional drug testing, for the most part, only provides a general idea of drug levels in a patient’s system and sometimes can only provide yes/no answers. CORE dives deeper, evaluating both if the drug is in a patient’s system AND if the measured drug concentration is likely within the expected steady state range for that patient’s prescribed dose and frequency.


CORE is a tool to help document adherence to a dosing regimen while adding another level of protection to the provider’s practice. CORE can give information to providers to help identify lower-risk patients on chronic prescriptions who are likely at steady state. CORE can help flag those patients that may not be at steady state and potentially require closer monitoring. Without CORE, a positive drug test for a prescribed medication would otherwise be viewed as a consistent result; thus, CORE can help reduce potential fraud, waste and abuse.


CORE tells you whether a drug is present in the patient’s system and helps indicate whether the drug concentration is within the expected steady state range for that patient’s prescribed dosing regimen. This gives providers additional insight to help:

  • Document that a patient has likely reached the expected steady-state range for their prescribed medication before increasing dosage.
  • Provide insight on whether metabolic genetic testing may be clinically indicated and medically warranted.
  • Review the treatment plan with the patient and determine if changes in prescription regimen or medical intervention may be needed to provide optimum patient care for the patient’s medical condition.


Because oral fluid is a filtrate of blood, it is affected by significantly fewer variables than urine; and because oral fluid can be an easily observed collection, it has a much lower risk of sample adulteration or substitution.

“As a research partner of Cordant and specifically CORE testing, I have had the opportunity to evaluate test results within my patient population. I have found the added information to be powerful in understanding how and when a patient is taking their medications, many times leading to a more informed conversation with a patient. CORE gives a better indication of dose compliance – and this is especially important in light of new CDC guidelines.”

—Naum Shaparin, M.D.
Director of Pain Services
Montefiore Medical Center


  • Oxycodone
  • Hydrocodone
  • Morphine
  • Oxymorphone
  • Hydromorphone
  • Tramadol
  • Fentanyl

*Patients falling within range may still have genetic abnormalities.  Test results should not be substituted for professional clinical judgment.

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