Using blood for drug testing provides invaluable information on compliance with medication regimens, court mandates, substance-abuse treatment, and other directives. When it becomes pertinent to know how much of a substance is present, how that quantity compares to a person’s dosing regimen, and/or how the individual is metabolizing a prescribed medication, then it may be time to use blood testing. Blood has a shorter window of detection than urine, but it can provide substantial insights into recent medication use and illicit drug use.


It is important to implement a medication-monitoring protocol by utilizing baseline and ongoing randomized clinical toxicology laboratory testing with a variety of specimen types—urine, oral fluid, blood, and hair. Blood testing is very useful for high-risk patients because it can provide a detailed picture of the patient’s habits and metabolism.

* It is imperative the patient be in steady state with the medication before you request a blood dose correlation. It is impossible to receive accurate information from a blood dose correlation for medication that is taken only “as needed,” for testing of new patients, or for testing of a patient who has recently changed medication or dose.


  • Supports positive correlation between drug and blood concentrations
  • Identifies if more or less medication is being taken than prescribed
  • Documents patient tolerance to potentially toxic levels of medication
  • Determines the need for additional testing (such as pharmacogenetic testing)
  • Provides unequivocal identification of parent drug


Blood analysis results can be correlated to the dose of drug taken when a patient is at steady state.* Patients taking a daily dose of a prescribed medication for the treatment of pain should, over time, reach a steady-state blood concentration level that reflects the prescribed dose. The purpose of this testing is to correlate the amount of drugs a patient is taking with the amount that is in their system, known as blood dose correlation. Cordant uses a proprietary algorithm involving factors to determine if a patient is above, below or within the reference range:

  • Medication of interest
  • Prescribed dose of medication
  • Accurate patient weight
  • Frequency of prescribed dose
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